右美託咪定是α2-腎上腺素受體激動劑，在臨床應用及研究中發現它具有鎮靜、抗炎、預防譫妄等多種作用。
右美託咪定對腸道手術患者的抗炎作用：一項隨機研究
背景與目的：
右美託咪定是一種高選擇性α2-腎上腺素能受體激動劑，具有鎮靜、鎮痛、抗交感和減壓作用。它已被廣泛用於多種手術的全身麻醉輔助。然而，在腸道手術中使用右美託咪定與患者術後炎症反應之間的關係尚不清楚。
方法：
採用隨機、對照、單盲臨床試驗。招募了86名腸道手術患者，並將其隨機分為兩組（右美託咪定組，n=40；對照組，n=40）［由於多種原因，如過敏和藥物使用史，排除了6名參與者］。詳見下圖。
收集並分析接受不同治療（右美託咪定和0。9%氯化鈉）的參與者的臨床特徵和生理結果。
兩組在給藥前（T0）、泵入右美託咪定/生理鹽水（T1）後10分鐘、手術開始後立即（T2）、手術開始後30分鐘（T3）和手術結束後立即（T4）採集血樣。採用酶聯免疫吸附試驗（ELISA）檢測促炎因子。
結果：
腸道手術前靜脈注射右美託咪定可降低多種迴圈促炎因子，右美託咪定減輕了腸道手術患者的應激反應。
右美託咪定減少了拔管時間，自主呼吸恢復更快，降低了瑞芬太尼用量。
促進了認知能力的恢復。
右美託咪定組各種副反應更少。
結論：
右美託咪定可抑制腸道手術患者術後的炎症反應。
原文摘要
TheAnti-inflammatory Effect of Dexmedetomidine Administration on PatientsUndergoing Intestinal Surgery： A Randomized Study
Backgroundand objective： Dexmedetomidine is a highly selective α2-adrenergic receptoragonist with sedative， analgesic， anti-sympathetic and stress-reducing effects。It has been widely used as an adjunct for general anesthesia of multiplesurgeries。 However， the relationship between the utilization of dexmedetomidinein intestinal surgery and the postoperative inflammatory response of patientsremains unclear。
Methods：A randomized， controlled， single-blinded clinical trial was performed。Eighty-six patients assigned for intestinal surgery were recruited and wererandomly divided into two groups （dexmedetomidine group， n = 40； control group，n = 40） ［six participants were excluded due to multiple reasons， such asallergy and drug use history］。 The clinical characteristics and physiologicaloutcomes of participants who received different treatments （dexmedetomidine and0。9% sodium chloride） were collected and analyzed。 Blood samples of the twogroups were collected before administration （T0）， 10 min after pumpingdexmedetomidine/saline solution （T1）， immediately after the operation started（T2）， 30 min after the operation started （T3）， and immediately after theoperation ended （T4）。 Enzyme-linked immunosorbent assay （ELISA） was performedto evaluate the proinflammatory factors。
Results：Intravenous injection of dexmedetomidine before intestinal surgery decreased avariety of circulating proinflammatory factors。 Dexmedetomidine alleviated thestress response and promoted the recovery of cognitive ability among patientsundergoing intestinal surgery。
Conclusion：Dexmedetomidine administration in patients undergoing intestinal surgeryinhibited the surgery-induced inflammatory reactions。